Der Folsäure-Antagonist Methotrexat wird im Off-label-Use eingesetzt, wenn Azathioprin oder 6-Mercaptopurin erfolglos waren oder deren Therapie aufgrund von Nebenwirkungen beendet werden musste. Zu Behandlungsbeginn werden wöchentlich 25 mg MTX intramuskulär gespritzt, da die Aufnahme über den Magen-Darm-Trakt individuell stark schwankt. Ist die Krankheit in eine inaktive Phase überführt. Dosing for other off-label use may vary according to what disease is being treated; in general, off-label use should be done by an experienced medical specialist. Azathioprine should be taken with food. Purinethol is prescribed for the maintenance treatment of acute lymphatic leukemia (ALL). This eMedTV selection contains more details on the uses of Purinethol and includes a description of how it works. A list of off-label uses is also provided. Purinethol is prescribed for the maintenance treatment of acute lymphatic leukemia (ALL). This eMedTV selection contains more details on the uses of Purinethol and includes a description of how it works. A list of off-label uses is also provided. Medscape - Indication-specific dosing for Purinethol, 6Mercaptopurine (mercaptopurine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Mercaptopurine was introduced into use in the 1950s for the therapy of leukemia and lymphoma and was formally approved for use in the United States in 1953. It is still used in therapy of acute lymphocytic leukemia and off-label for autoimmune conditions such as Crohn’s disease. Mercaptopurine is available generically and under the brand name of Purinethol as tablets of 50 mg. The usual dose. What About Off-Label Uses? On occasion, your healthcare provider may recommend this medicine for treating something other than the condition discussed in this article. This is called an off-label use. The patient or caregiver may administer after being properly trained on proper storage, preparation, administration, disposal, and clean-up. The patient or caregiver should read and follow the instructions for use provided by manufacturer. Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease , and ulcerative colitis. Negative 24 Evidently there is one in Purinethol that I cannot take. I had several bouts of nausea and fainting and to make sure it was the Purinethol I even went off it for a few days and when I took it again within a couple of hours I was deathly sick and even passed out several times.